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Title: Synthesis of self-assembly of agarose-fatty acid ester nanoparticles
Authors: Kondaveeti, Stalin
Chejara, Dharmesh R
Siddhanta, A K
Keywords: Nanoparticles;Self-assembly;Hydrophobization;Natural polymers;Polysaccharides;Carbodiimides;Agarose;Fatty acid esters;Stearic acid;Palmitic acid;Microwave synthesis
Issue Date: 3-Jun-2014
Abstract: Microwave assisted facile synthesis of hydrophobically modified nano-sized particulate esters of agarose and stearic and palmitic acids (Ag-SA and Ag-PA), employing carbodiimide chemistry has been described. The hydrophobically modified agarose is capable of forming self-assembled nano-sized particles. Physicochemical characterization of Ag-SA, Ag-PA has been carried out by gel permeation chromatography, differential scanning calorimetric, scanning electron microscopy and FT-IR, 13C-NMR and 1H-NMR spectra. The aqueous self-assembly of the modified polymer has been studied by dynamic light scattering and transmission electron microscopy, which shows the formation of 4-5 nm micelles, and 220-250 nm polymeric vesicles. TEM images demonstrate that the self-aggregate is spherical in shape. These new agarose based nano-sized materials may be of potential utility in biomedical applications as drug delivery vehicles.
Page(s): 679-687
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.53A(06) [June 2014]

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