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Title: Validated liquid chromatographic method for simultaneous estimation of albendazole and ivermectin in tablet dosage form
Authors: Waldia, Anil
Gupta, Shubash
Issarani, Roshan
Nagori, Badri P
Keywords: RP-HPLC
Albendazole
Ivermectin
Validation
Issue Date: Nov-2008
Publisher: CSIR
Abstract: A reverse phased liquid chromatography (LC) method was developed and validated for simultaneous estimation of albendazole and ivermectin in tablet dosage form. The isocratic LC analysis was performed on NUCLEODUR C18 RP column (250 x 4.6 mm, 5 µ) using mobile phase composed of acetonitrile, methanol and water in ratio of 60:30:10 (v/v/v) at a flow rate of 1.8 mL/min. Quantitation was performed using UV detector at 245 nm and the run time was 20 min. The retention times were found to be 3.56 min for albendazole and 10.08 min for ivermectin. The analytical method was validated according to ICH guidelines. The linearity was observed in the range of 400–800 and 6–12 μg/mL with correlation coefficient, r=0.9975 and 0.9969 for albendazole and ivermectin respectively. The relative standard deviation values for repeatability and intermediate precision studies were less than 2%, and the accuracy (% recovery) was greater than 98% for both the drugs. The method was successfully applied for market sample analysis and mean percentage assay values were 98.68±0.28 and 98.67±0.50 for albendazole and ivermectin respectively. The present method is precise and accurate and can be used for the routine estimation of albendazole and ivermectin in tablet dosage forms.
Page(s): 617-620
ISSN: 0971–457X
Source:IJCT Vol.15(6) [November 2008]

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