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Title: Synthesis, computational study, configurational analysis and biological activity of imidazolidinone, thiazolidinone and isoxazolone derivatives of 1,2-naphthoquinone
Authors: Pardasani, R T
Prashant, Anita
Sharma, Kusum
Keywords: Knoevenagel condensation;Naphthoquinone;Imidazolidinone;Thiazolidinone;Isoxazolone;DFT calculations;Antimicrobial activity
Issue Date: May-2014
Publisher: NISCAIR-CSIR, India
Abstract: The Knoevenagel type condensation reactions of 1,2-naphthoquinone with imidazolidinone, thiazolidinone and isoxazolone derivatives have been described. The synthesized products have been characterized by physical and spectroscopic techniques. DFT calculation revealed that the heat of formation (∆Hf) of monocondensation products are much lower than the corresponding biscondensation products, suggesting their feasibility and thermodynamic stability. Newly synthesized products show significant antibacterial and antifungal activity.
Page(s): 619-624
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.53B(05) [May 2014]

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