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|Title:||Synthesis, computational study, configurational analysis and biological activity of imidazolidinone, thiazolidinone and isoxazolone derivatives of 1,2-naphthoquinone|
|Authors:||Pardasani, R T|
|Keywords:||Knoevenagel condensation;Naphthoquinone;Imidazolidinone;Thiazolidinone;Isoxazolone;DFT calculations;Antimicrobial activity|
|Abstract:||The Knoevenagel type condensation reactions of 1,2-naphthoquinone with imidazolidinone, thiazolidinone and isoxazolone derivatives have been described. The synthesized products have been characterized by physical and spectroscopic techniques. DFT calculation revealed that the heat of formation (∆Hf) of monocondensation products are much lower than the corresponding biscondensation products, suggesting their feasibility and thermodynamic stability. Newly synthesized products show significant antibacterial and antifungal activity.|
|Appears in Collections:||IJC-B Vol.53B(05) [May 2014]|
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