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Title: Microemulsion technique for the novel synthesis of deferasirox using metal mediated coupling
Authors: Roy, Bhairab Nath
Singh, Girij Pal
George, Shaji K
Lathi, Piyush S
Agrawal, Manoj K
Trivedi, Anurag
Mishra, Madhan
Singh, Gajendra
Keywords: Deferasirox;Chan-Lam coupling;Suzuki coupling;Microemulsion;Metal mediated synthesis
Issue Date: May-2014
Publisher: NISCAIR-CSIR, India
Abstract: A novel and efficient synthesis of Deferasirox has been accomplished using transition metal catalyzed sequential cross coupling reactions. First stage of the synthesis employs the use of Chan-Lam coupling between 3,5-dibromo-1H[1,2,4]triazole and (4-(methoxycarbonyl)-phenyl)boronic acid to give methyl 4-(3,5-dibromo-1H-1,2,4-triazol-1-yl)benzoate which is further elaboarated to Deferasirox by Suzuki-Miyaura coupling with 2-hydroxyphenyl-boronic acid pinacol ester in microemlusion.
Page(s): 610-618
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.53B(05) [May 2014]

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