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Title: An aqua mediated facile synthesis of conformationally restricted polycyclic dihydropyridines
Authors: Kidwai, Mazaahir
Kukreja, Shuchi
Rastogi, Shweta
Singhal, Kavita
Mishra, Neeraj Kumar
Keywords: Conformationally restricted dihydropyridines;4-hydroxycoumarin;Aqueous medium;Microwaves
Issue Date: May-2014
Publisher: NISCAIR-CSIR, India
Abstract: An economically and environmentally benign synthesis of 4-substituted-dihydropyridines (DHPs) is described from readily accessible 4-hydroxy coumarin with aldehydes and ammonium nitrate that are accelerated by exposure to microwaves. The reaction completes within a few minutes with good yields. The mechanistic detail of methodology includes Michael type addition of β-aminobenzopyran-2-one across the double bond of arylidine formed by the condensation of 4-hydroxycoumarin with aldehyde in aq. medium. The main advantages of the protocol reported here is absence of use of strong acid or expensive catalyst, good yields, easy work-up and almost no effluent generation.
Page(s): 605-609
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.53B(05) [May 2014]

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