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IJCT Vol.15(6) [November 2008] >

Title: Voltammetric DNA biosensor for the study of mechanism of action of anticancer drug-adriamycin
Authors: Tiwari, Sweety
Pitre, K S
Keywords: Modified electrode
Anthracycline compound
Issue Date: Nov-2008
Publisher: CSIR
Abstract: The interaction of anticancer drug adriamycin with DNA has been studied using voltammetric DNA biosensor. The binding mechanism of adriamycin was elucidated by using differential pulse voltammetry (DPV) at DNA modified glassy carbon fiber electrodes (GCFE). The decrease in guanine oxidation peak current at +0.9 V was used as an indicator for interaction mechanism in acetate buffer (pH 4.5). The studied drug-DNA interaction mechanism at charged electrode surface is similar to the in-vivo DNA-drug complex formation, where DNA is in close contact with charged phospholipid membranes and proteins. Thus, the fabricated biosensor helps in understanding the in-vivo mechanism of action of this anticancer drug.
Page(s): 593-597
ISSN: 0971–457X
Source:IJCT Vol.15(6) [November 2008]

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