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Title: Comparative study of haematinic and iron utilization property of pre and flowering plant leaf extracts of Asteracantha longifolia (L.) Nees
Authors: Dutta, Goutam Kumar
Thakur, Kamlesh
Mandal, Sanju
Dash, Amit Kumar
Keywords: Hygrophila auriculata (Schumach.) Heine;Anaemia;Free haemoglobin;Serum iron;Lipid peroxidation
Issue Date: Apr-2014
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.8: A61K 36/00, A61, A01G 20/00, A61K 35/16, B44F 9/10, C01B 13/14, G06M 11/02, G01N 33/48
Abstract: The study was conducted to validate and compare the haematinic property of pre-flowering and flowering Asteracantha longifolia (L.) Nees leaf extract. A phenylhydrazine induced anaemic rat model was used for this study. Concentrate hot water extract of succulent aerial part of pre-flowering and flowering leaf was orally administered @ 40 mg kg-1 body weight for 30 days, and equivalent weight of crude leaf was also administered to observe as well as to compare the amelioration and iron utilization. Pre- flowering extract effectively improved the concentration of membrane bound haemoglobin, RBC indices, and concentration of serum copper and cobalt; and normalized free haemoglobin concentration, percent of haematocrit, serum cobalt concentration, and lipid peroxidation. Pre-flowering extract also normalized the serum iron concentration. This observation could justify the indusion of pre-flowering extract to ameliorate anaemic condition caused by haemolysis due to the reduction of serum iron and free haemoglobin concentration and improvement of RBC bound haemoglobin concentration. The plant extract contains anti-oxidants and other constituents like, Cu, Co, Fe.
Page(s): 352-358
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.13(2) [April 2014]

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