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Title: Effect of microbial load on therapeutically active constituent glycyrrhizin of Glycyrrhiza glabra L.
Authors: Agarwal, Manisha
Rai, Vartika
Khatoon, Sayyada
Mehrotra, Shanta
Keywords: Glycyrrhizin;Herbal drugs;Liquorice;Microbial contamination;HPTLC
Issue Date: Apr-2014
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, C12Q, A61P, A61J
Abstract: Contamination of herbal drugs by microbes is a very common phenomenon as many reports are available, but what alteration occurs on secondary metabolites of plants due to these has very few records. In the present study, it has been established that the concentration of glycyrrhizin (active constituent) decreases by microbial contamination. The contamination of ten fungal species, viz. Aspergillus niger Tiegh., A. flavus Link, A. fumigates Fresentius, A. sydowii Thom & Church, Penicillium chrysogenum Thom, P. purpurogenum Stoll, Alternaria alternate (Fr.) Keissl., Cladosporium sphaerospermum Penz., Absidia corymbifera Sacc. & Trott., Rhizopus oryzae Went & Prins. Geerl. and three bacteria, viz. Escherichia coli (Migula) Castell. & Chalm., Pseudomonas aeruginosa (Schroeter) Migula and Salmonella Lignieres has been perceived in the samples of liquorice. Besides, a correlation between moisture, sugar, starch and microbial load has also been established. It was found that the sample having maximum moisture percentage had heavy microbial load. On the contrary, sugar and starch percentage were minimum in the same sample.
Page(s): 319-324
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.13(2) [April 2014]

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