Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/27901
Title: One-pot synthesis of novel symmetric 1,5-di(benzofuran-2-yl)-3-(4-substituted-aryl)-pentane-1,5-dione derivatives
Authors: Kumar, Aruna D B
Desai, Nivedita R
Krishnaswamy, G
Sreenivasa, S
Mahadevan, K M
Keywords: Benzofuran;Solvent free condition;Crossed aldol condensation;α,β-unsaturated carbonyls;Michael addition;1,5-dicarbonyl derivatives;One pot synthesis
Issue Date: Apr-2014
Publisher: NISCAIR-CSIR, India
Abstract: Salicylaldehyde and its substituted derivatives on reaction with bromoacetone under basic condition in ethanol afford corresponding benzofuran derivatives 1a-d. The compounds 1a-d on treatment with different para substituted aromatic aldehydes in presence of base and minimum amount of acetonitrile upon grinding at room temperature gives corresponding α,β-unsaturated carbonyl compounds by crossed aldol condensation, which further undergo Michael addition with 2-acetyl benzofuran to give a new class of symmetric 1,5-di(benzofuran-2-yl)-3-(4-substituted-aryl)-pentane-1,5-dione derivatives 2a-p in one step. The structures of all the newly synthesized compounds have been established by spectral studies.
Page(s): 426-430
URI: http://hdl.handle.net/123456789/27901
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.53B(04) [April 2014]

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