Please use this identifier to cite or link to this item:
Title: An investigation leading to preparation of tetrahydro-quinazoline derivatives involving ureidoalkylation and ⍺-amidoalkylation reactions
Authors: Pandey, V K
Kumar, Anilesh
Trivedi, Noopur
Keywords: Ureidoalkylation
Spontaneous motor activity
Issue Date: Dec-2008
Publisher: CSIR
Abstract: Reaction of an aldehyde with excess equivalent of urea in ethanol affords alkylideno/arylideno-bis-ureas 1 which on condensation with p-aminophenol in acidic medium cyclised to 4-aralkyl-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines 2. Reaction of 2 with arylamidoalcohols in concentrated H2SO4 results in 4-arylkyl-7-arylamido/imidoalkyl-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines 3. Compounds 3 have been evaluated for their effect on central nervous system (CNS) and cardiovascular system (CVS).
Description: 1910-1914
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(12) December 2008]

Files in This Item:
File Description SizeFormat 
IJCB 47B(12) 1910-1914.pdf65.08 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.