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Title: An investigation leading to preparation of tetrahydro-quinazoline derivatives involving ureidoalkylation and ⍺-amidoalkylation reactions
Authors: Pandey, V K
Kumar, Anilesh
Trivedi, Noopur
Keywords: Ureidoalkylation;Tetrahydroquinazolines;Spontaneous motor activity
Issue Date: Dec-2008
Publisher: CSIR
Abstract: Reaction of an aldehyde with excess equivalent of urea in ethanol affords alkylideno/arylideno-bis-ureas 1 which on condensation with p-aminophenol in acidic medium cyclised to 4-aralkyl-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines 2. Reaction of 2 with arylamidoalcohols in concentrated H2SO4 results in 4-arylkyl-7-arylamido/imidoalkyl-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines 3. Compounds 3 have been evaluated for their effect on central nervous system (CNS) and cardiovascular system (CVS).
Page(s): 1910-1914
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(12) December 2008]

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