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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(12) December 2008] >
| Title: | An investigation leading to preparation of tetrahydro-quinazoline derivatives involving ureidoalkylation and ⍺-amidoalkylation reactions |
| Authors: | Pandey, V K
Mukesh
Kumar, Anilesh
Trivedi, Noopur |
| Keywords: | Ureidoalkylation
Tetrahydroquinazolines
Spontaneous motor activity |
| Issue Date: | Dec-2008 |
| Publisher: | CSIR |
| Abstract: | Reaction of an aldehyde with excess equivalent of urea in ethanol affords alkylideno/arylideno-bis-ureas 1 which on condensation with p-aminophenol in acidic medium cyclised to
4-aralkyl-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines 2. Reaction of 2 with arylamidoalcohols in concentrated H2SO4 results in 4-arylkyl-7-arylamido/imidoalkyl-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines 3. Compounds 3 have been evaluated for their effect on central nervous system (CNS) and cardiovascular system (CVS). |
| Page(s): | 1910-1914 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(12) December 2008]
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