Please use this identifier to cite or link to this item:
|Title:||Synthesis of some novel ethoxyphthalimide derivatives of pyrazolo[3,4-c]pyrazoles|
Talesara, G L
|Abstract:||The synthesis of 5-methyl-4-substituted benzylidene-2,4-dihydro-3H-pyrazol-3-one 3a-d is achieved by the condensation reaction of 5-methyl-2,4-dihydro-3H-pyrazol-3-one 1 with 4-substituted benzaldehydes 2a-d. Compound 1 is prepared by the cyclization reaction between ethylacetoacetate and hydrazine hydrate in absolute alcohol. Compounds 3a-d are converted into corresponding ethoxyphthalimide derivatives 5a-d by treatment with phthalimidoxyethyl bromide 4. 1-N-Ethoxyphthlimido-3-methyl-4-(4-substituted benzylidene)pyrazol-5-ones 5a-d are reacted with thiosemicarbazide/NaOH and isoniazid/AcONa/AcOH separately to yield 6-N-ethoxyphthalimido-4-methyl-3-(4-substituted phenyl)-2-thiocarbamoyl-3,3a-dihydro pyrazolo[3,4-c]pyrazoles 6a-d and 6-N-ethoxyphthalimido-2-isonicotinoyl-4-methyl-3-(4-substituted phenyl)-3,3a-dihydro pyrazolo[3,4-c]pyrazoles 7a-d respectively. Structures of the synthesized compounds have been elucidated by means of IR, 1H NMR and mass spectral data.|
|Appears in Collections:||IJC-B Vol.47B(12) December 2008]|
Files in This Item:
|IJCB 47B(12) 1892-1897.doc||149 kB||Microsoft Word||View/Open|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.