Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/2754
Title: Synthesis of some novel ethoxyphthalimide derivatives of pyrazolo[3,4-c]pyrazoles
Authors: Sharma, Chirag
Thadhaney, Bhawana
Pemawat, Gangotri
Talesara, G L
Keywords: Thiosemicarbazide
Isoniazid
Phthalimidoxyethyl bromide
Pyrazolo[3,4-c]pyrazoles
Issue Date: Dec-2008
Publisher: CSIR
Abstract: The synthesis of 5-methyl-4-substituted benzylidene-2,4-dihydro-3H-pyrazol-3-one 3a-d is achieved by the condensation reaction of 5-methyl-2,4-dihydro-3H-pyrazol-3-one 1 with 4-substituted benzaldehydes 2a-d. Compound 1 is prepared by the cyclization reaction between ethylacetoacetate and hydrazine hydrate in absolute alcohol. Compounds 3a-d are converted into corresponding ethoxyphthalimide derivatives 5a-d by treatment with phthalimidoxyethyl bromide 4. 1-N-Ethoxyphthlimido-3-methyl-4-(4-substituted benzylidene)pyrazol-5-ones 5a-d are reacted with thiosemicarbazide/NaOH and isoniazid/AcONa/AcOH separately to yield 6-N-ethoxyphthalimido-4-methyl-3-(4-substituted phenyl)-2-thiocarbamoyl-3,3a-dihydro pyrazolo[3,4-c]pyrazoles 6a-d and 6-N-ethoxyphthalimido-2-isonicotinoyl-4-methyl-3-(4-substituted phenyl)-3,3a-dihydro pyrazolo[3,4-c]pyrazoles 7a-d respectively. Structures of the synthesized compounds have been elucidated by means of IR, 1H NMR and mass spectral data.
Description: 1892-1897
URI: http://hdl.handle.net/123456789/2754
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(12) December 2008]

Files in This Item:
File Description SizeFormat 
IJCB 47B(12) 1892-1897.doc149 kBMicrosoft WordView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.