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Title: Synthesis of quinazolinone analogues using sodium perborate as catalyst
Authors: Kidwai, Mazaahir
Keywords: Sodium perborate;Quinazolin-4-ones;2-aminobenzonitrile;Microwave irradiation (MWI);Solvent-system
Issue Date: Dec-2008
Publisher: CSIR
Abstract: An environmentally benign approach for the synthesis of 2-aryl-3H-quinazolin-4-ones employing sodium perborate (SPB) as catalyst is described. SPB in water and acetone system is proved as selective catalyst of hydration for cyanides. The rate enhancement and high yield is attributed to the coupling of suitable catalyst with the solvent system. The key step is the microwave prompted reaction sequence combining 2-aminobenzonitrile and aromatic/heteroaromatic aldehydes providing efficient access to intermediate for the synthesis of this important class of nitrogen fused heterocycle.
Page(s): 1876-1881
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(12) December 2008]

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