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dc.contributor.authorRameshwar, N-
dc.contributor.authorParthasarathy, T-
dc.contributor.authorReddy, A Ram-
dc.description.abstractOne pot condensation of ethyl acetoacetate or methyl acetoacetate with various para and ortho substituted aromatic aldehydes and urea or thiourea by tin(IV) chloride affords twenty-one different substituted 3,4–dihydropyrimidin-2-(1H)-ones. Tin(IV) chloride has emerged as a powerful catalyst for the preparation of 3,4–dihydropyrimidin-2-(1H)-ones under simple and mild conditions. It is compatible with a wide variety of substituents in the aromatic aldehyde. Substituents at para position in aldehyde are more effective than the substituents at ortho position. Both the β–ketoesters, and urea or thiourea are equally effective towards an efficient 3,4–dihydropyrimidin-2-(1H)-one synthesis.en_US
dc.sourceIJCB Vol.47B(12) [December 2008]en_US
dc.subjectBiginelli reactionen_US
dc.subjectTin(IV) chlorideen_US
dc.subjectSolvent-free conditionen_US
dc.titleTin(lV) catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditionsen_US
Appears in Collections:IJC-B Vol.47B(12) December 2008]

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