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IJC-B Vol.47B(12) December 2008] >


Title: Tin(lV) catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions
Authors: Rameshwar, N
Parthasarathy, T
Reddy, A Ram
Keywords: Biginelli reaction
Dihydropyrimidinones
Tin(IV) chloride
Solvent-free condition
Issue Date: Dec-2008
Publisher: CSIR
Abstract: One pot condensation of ethyl acetoacetate or methyl acetoacetate with various para and ortho substituted aromatic aldehydes and urea or thiourea by tin(IV) chloride affords twenty-one different substituted 3,4–dihydropyrimidin-2-(1H)-ones. Tin(IV) chloride has emerged as a powerful catalyst for the preparation of 3,4–dihydropyrimidin-2-(1H)-ones under simple and mild conditions. It is compatible with a wide variety of substituents in the aromatic aldehyde. Substituents at para position in aldehyde are more effective than the substituents at ortho position. Both the β–ketoesters, and urea or thiourea are equally effective towards an efficient 3,4–dihydropyrimidin-2-(1H)-one synthesis.
Page(s): 1871-1875
ISSN: 0376-4699
Source:IJC-B Vol.47B(12) December 2008]

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