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Title: Synthesis of N-(substituted benzyl)-2-(3′,5′-dimethyl-4′-hydroxyphenyl) acetamides
Authors: Raju, B China
Keywords: Acetamides;4-benzyloxy-3,5-dimethylphenylacetate;Substituted benzyl amines;Tetrahydroisoquinolines
Issue Date: Dec-2008
Publisher: CSIR
Abstract: 4-Benzyloxy-3,5-dimethylphenylacetate 1 reacts with substituted benzyl amines 2a-e affords N-substituted benzyl-2-(4′-benzyloxy-3′,5′-dimethylphenyl) acetamides 3a-e, which on debenzylation give N-substituted benzyl-2-(3′,5′-dimethyl-4′-hydroxy phenyl) acetamides 4a-e in very good yields which are important intermediates for the synthesis of 1,2,3,4-tetrahydroisoquinolines.
Page(s): 1903-1905
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(12) December 2008]

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