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|Title:||Synthesis of N-(substituted benzyl)-2-(3′,5′-dimethyl-4′-hydroxyphenyl) acetamides|
|Authors:||Raju, B China|
|Keywords:||Acetamides;4-benzyloxy-3,5-dimethylphenylacetate;Substituted benzyl amines;Tetrahydroisoquinolines|
|Abstract:||4-Benzyloxy-3,5-dimethylphenylacetate 1 reacts with substituted benzyl amines 2a-e affords N-substituted benzyl-2-(4′-benzyloxy-3′,5′-dimethylphenyl) acetamides 3a-e, which on debenzylation give N-substituted benzyl-2-(3′,5′-dimethyl-4′-hydroxy phenyl) acetamides 4a-e in very good yields which are important intermediates for the synthesis of 1,2,3,4-tetrahydroisoquinolines.|
|Appears in Collections:||IJC-B Vol.47B(12) December 2008]|
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