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Title: Protective effect of alcoholic extract of Entada pursaetha DC. against CCl4-induced hepatotoxicity in rats
Authors: Gupta, Gaurav
More, Amar Sunil
Kumari, Rashmi Rekha
Lingaraju, Madhu Cholenahalli
Kumar, Dhirendra
Kumar, Dinesh
Mishra, Santosh Kumar
Tandan, Surender Kumar
Keywords: Antioxidant;CCl4;Entada pursaetha;Hepatoprotection Liver toxicity
Issue Date: Mar-2014
Publisher: NISCAIR-CSIR, India
Abstract: The alcoholic extract of stem of E. pursaetha (PSE, 30, 100, 300 mg/kg body weight, po for 7 days) showed hepatoprotective activity against CCl4 (2 mL/kg body weight, ip)-induced hepatotoxicity. The extract exhibited a significant dose-dependent hepatoprotective effect comparable to standard drug silymarin, by preventing increase in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and total bilirubin, lactate dehydrogenase; by lowering hepatic levels of malonaldehyde, nitrate-nitrite, myeloperoxidase activity; enhancing activities of antioxidant enzymes, superoxide dismutase, catalase and increasing reduced glutathione levels in liver, which suggests the antioxidant property of PSE. Histopathological studies also supported the above biochemical parameters. The results suggested that alcoholic extract of E. pursaetha possesses significant hepatoprotective activity in CCl4-induced acute hepatotoxicity in rats and this is likely to be mediated through its antioxidant activities.
Page(s): 207-214
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.52(03) [March 2014]

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