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Title: Chemical Synthesis of Triazolil-Thiazolidin and Erylidins: Antibacterial and Antiinflammatory Agent
Authors: Srivastava, S D
Srivastava, Somya
Srivastava, S K
Issue Date: Jun-2003
Publisher: NISCAIR-CSIR, India
Abstract: By the reaction o f 1,2,4,-triazole/benzotriazol and ethyl chloroacetate, their acetates are formed (1) which produce (acetohydrazaedo)- 1,2,4- triazole/benzotriazol on reacting with hydrazine hydrate. By condensing product(2) with different substituted aromatic aldehydes, erylidine acetohydrazydo-1,2,4-triazole/benzotriazols (3) is obtained which produces 2- (substituted eryl)-3-(1 ,2,4-triazolil benzotriazolil acetamidil )-4-oxothiazolidins (4) by the cyclic additional reaction with mercaptoacetic acid which again synthesize 5-erylidin-2-eryl-3-(1 ,2,4-triazolil/benzotiazolil acetaamydil)-1,3-thiazolidin-4-ones (5) after reacting with aromatic aldehydes, the structure of these products was confirmed on the basis of spectrometry elementary analysis. Antibacterial and anti-inflammatory screening was carried out of all the activities thus obtained.
Page(s): 58-60
ISSN: 0975-2412 (Online); 0771-7706 (Print)
Appears in Collections:BVAAP Vol.11(1) [June 2003]

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