|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.45 [2008] >
IJBB Vol.45(6) [December 2008] >
| Title: | Localization of Heme Biosynthesis Pathway Enzymes in Plasmodium falciparum |
| Authors: | Rao, Aditya
Yeleswarapu, Sri Jyothsna
Srinivasan, Rajgopal
Bulusu, Gopalakrishnan |
| Keywords: | Plasmodium falciparum
Localization
Apicoplast
Mitochondrion
Heme biosynthesis
Heme pathway enzymes |
| Issue Date: | Dec-2008 |
| Publisher: | CSIR |
| Abstract: | Protein trafficking in the malarial parasite Plasmodium falciparum is dictated by a complex life-cycle that involves a variety of intra-cellular and host cell destinations, such as the mitochondrion, apicoplast, rhoptries and micronemes. Of these, the apicoplast and mitochondrion are believed to account for more than 10% of this traffic. Studies have shown that mechanisms for mitochondrion and apicoplast targeting are distinct, despite their close physical proximity. The heme biosynthesis pathway spans both these organelles, making trafficking studies crucial for the spatial demarcation of the constituent interactions. This minireview highlights the challenges in identifying the possible sub-cellular destinations of the heme pathway enzymes using gleanings from literature survey as well as focussed bioinformatic analysis. |
| Page(s): | 365-373 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.45(6) [December 2008]
|
|
