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Title: Localization of Heme Biosynthesis Pathway Enzymes in Plasmodium falciparum
Authors: Rao, Aditya
Yeleswarapu, Sri Jyothsna
Srinivasan, Rajgopal
Bulusu, Gopalakrishnan
Keywords: Plasmodium falciparum;Localization;Apicoplast;Mitochondrion;Heme biosynthesis;Heme pathway enzymes
Issue Date: Dec-2008
Publisher: CSIR
Abstract: Protein trafficking in the malarial parasite Plasmodium falciparum is dictated by a complex life-cycle that involves a variety of intra-cellular and host cell destinations, such as the mitochondrion, apicoplast, rhoptries and micronemes. Of these, the apicoplast and mitochondrion are believed to account for more than 10% of this traffic. Studies have shown that mechanisms for mitochondrion and apicoplast targeting are distinct, despite their close physical proximity. The heme biosynthesis pathway spans both these organelles, making trafficking studies crucial for the spatial demarcation of the constituent interactions. This minireview highlights the challenges in identifying the possible sub-cellular destinations of the heme pathway enzymes using gleanings from literature survey as well as focussed bioinformatic analysis.
Page(s): 365-373
ISSN: 0301-1208
Appears in Collections:IJBB Vol.45(6) [December 2008]

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