Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/26628
Title: Biological Activity of Withanolides
Authors: Budhiraja, R D
Krishan, Pawan
Sudhir, S
Issue Date: Nov-2000
Publisher: NISCAIR-CSIR, India
Abstract: A large number of withanolides are isolated from solanaceous plants and some derivatives are also prepared. Some of the withanolides, mainly Withaferin A(WA),Withanolide D(WD), Withanolide E(WE), 3β- hydroxy-2,3-dihydrowithanolide F, and sitoindosides are assessed for biological activities. These compounds and some other withanolides are found to have useful biological effects such as anticancer, radiosensitizing, antibacterial, adaptogenic, immunomodulating, antioxidant , hepatoprotective, antistress, antiinflammatory antiarthritic, and insect antifeedant activities. However, none of the withanolide has so far been evaluated for pharmacokinetic and pharmacodynamic properties. The biological activities of the withanolides vary with the substitution pattern of the compounds. Further, several withanolides are present in each plant. Thus the detailed pharmacological studies of the withanolides are warranted before any of these compound can be clinically assessed and used.
Page(s): 904-911
URI: http://hdl.handle.net/123456789/26628
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.59(11) [November 2000]

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