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Title: Synthesis of Some New 1-[5'-{(2-benzothiazolylthio)methyl}-1', 3', 4'-thiadiazol-2'-yl]-4-substituted-3-chloro-2-azetidinones : Antimicrobial Agent
Authors: Guru, Niharika
Srivastava, S D
Issue Date: Jul-2001
Publisher: NISCAIR-CSIR, India
Abstract: A series of 2-arylideneamino-5-[(2-benzothiazolylthio) methyl]-1', 3', 4'-thiadiazoles (4a-j) have been synthesized via condensation of 2-amino-5-[(benzothiazolylthio)methyl]-1, 3, 4, thiadizole 3 with various carbonyl compounds. Cycloaddition of chloroacetylchloride to 4 gives 1-[5'-{(2-benzothiazolylthio) methyl}-1', 3', 4'-thiadiazol-2'-yl] -4-substituted -3-chloro-2-azetidinones (5a-j) have been synthesized as the final products. All the products have been screened for their antifungal and antibacterial activity against some selected pathogens and found to exhibit mild to pronounce activity.
Page(s): 601-605
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.60(07) [July 2001]

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