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|Title:||Synthesis of some novel class of isoxazoline and isoxazolidine derivatives in ionic liquid via 1,3-dipolar cycloaddition reaction of dihydropyran derived nitrones and their antimicrobial activities|
Sharma, Chiran Devi
|Keywords:||Dihydropyran derived nitrones;Cycloaddition reaction;Novel isoxazolidine & isoxazolines;Ionic liquid;Peptides;Aldehyde synthesis;Antimicrobial activity|
|Abstract:||1,3-Dipolar cycloaddition of dihydropyran derived nitrones synthesized from 2,3 dihydro 4H-pyran and various hydroxylamines, with electron deficient alkynes are found to have significant rate acceleration and improved yields of isoxazolines in 1-Butyl-3-methylimidazolium based ionic liquids while with enals exclusively endo isoxazolidines are obtained with high selectivity. Synthetic potentiality of the novel isoxazolines and nitrones have been also tested successfully in peptide and aldehyde synthesis. All the novel isoxazoline and isoxazolidine derivatives have been screened for antimicrobial activities and found to be active.|
|Appears in Collections:||IJC-B Vol.53B(02) [February 2014]|
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