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Title: Synthesis and biological evaluation of some new 2,5-disubstituted 1,3,4-oxadiazoles from 3-(arylsulfonyl) propanehydrazides
Authors: Kumar, L Vinay
Naik, P Jagan
Naveen, M
Chandrasekhar, T
Reddy, A Babul
Penchalaiah, N
Swamy, G Narayana
Keywords: Sulfone;2,5-disubstituted-1,3,4-oxadiazole;3-(arylsulfonyl) propanehydrazide;Antimicrobial activity
Issue Date: Feb-2014
Publisher: NISCAIR-CSIR, India
Abstract: Methyl acrylate on treatment with aryl thiols gives methyl 3-(arylthio) propanoates. The latter on oxidation with hydrogen peroxide followed by reaction with hydrazine hydrate gives 3-(arylsulfonyl) propanehydrazides. Two new series of 2,5-disubstituted-1,3,4-oxadiazoles from 3-[(4-chlorophenyl)sulfonyl] propane hydrazide and 3-[(4-methylphenyl)-sulfonyl] propane hydrazide have been synthesized and tested for antimicrobial activities. Some of these compounds have shown good antimicrobial activity.
Page(s): 208-211
ISSN:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
Appears in Collections:IJC-B Vol.53B(02) [February 2014]

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