Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/26440
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dc.contributor.authorPrasad, Satyendra K-
dc.contributor.authorLaloo, Damiki-
dc.contributor.authorKumar, Rajesh-
dc.contributor.authorSahu, Alakh N-
dc.contributor.authorHemalatha, S-
dc.date.accessioned2014-02-05T09:53:33Z-
dc.date.available2014-02-05T09:53:33Z-
dc.date.issued2014-02-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/26440-
dc.description139-146en_US
dc.description.abstractThe antidiarrhoeal activity of Cryptocoryne spiralis rhizomes extract (250, 500, 750 mg/kg, po) was evaluated using faecal excretion, castor oil-induced diarrhoea, small intestinal transit, intestinal fluid accumulation, gastric emptying and PGE2 induced enteropooling models in rats. In addition, various biochemical estimations, histopathological studies and antibacterial evaluations on strains responsible for diarrhoea were also performed. The results illustrated a significant reduction in normal faecal output rate after 5th and 7th h of treatment, while castor oil-induced diarrhoea model depicted a protection of 55.44% at same dose level from diarrhoea. The other models except, gastric emptying test demonstrated more pronounced effect at same dose level. A significant inhibition in nitric oxide, increase in carbohydrates, protein, DNA, Na+ and K+ level with minimum degeneration of colonic fibrous tissues and potent antibacterial activity were also observed. The antidiarrhoeal potential of C. spiralis may be as a result of antimotility and antisecretory type effect mediated through nitric oxide pathway.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.52(02) [February 2014]en_US
dc.subjectAconitum heterophyllumen_US
dc.subjectAntidiarrhoeal activityen_US
dc.subjectCastor oil induced diarrhoeaen_US
dc.subjectCryptocoryne spiralisen_US
dc.subjectPGE2 induced enteropoolingen_US
dc.subjectSmall intestinal transiten_US
dc.titleAntidiarrhoeal evaluation of rhizomes of Cryptocoryne spiralis Fisch. ex Wydler: Antimotility and antisecretory effectsen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.52(02) [February 2014]

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