Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/2552
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dc.contributor.authorKhare, Naveen K-
dc.contributor.authorReynolds, Robert C-
dc.contributor.authorMaddry, Joseph A-
dc.date.accessioned2008-12-05T06:11:46Z-
dc.date.available2008-12-05T06:11:46Z-
dc.date.issued2008-11-
dc.identifier.issn0376-4699-
dc.identifier.urihttp://hdl.handle.net/123456789/2552-
dc.description1748-1752en_US
dc.description.abstractThe first chemical synthesis of disaccharides, octyl 5-O-(4-deoxy-4-thio-⍺-D-arabinofuranosyl)-⍺-D-arabinofuranoside 1 and octyl 5-O-(4-deoxy-4-thio-β-D-arabinofuranosyl)-⍺-D-arabinofuranoside 2 incorporating 4-deoxy-4-thioarabinose is described. Designed to mimic components of mycobacterial arabinogalactan, a major and essential constituent of the cell wall of tuberculosis and related bacteria, the compounds may disrupt cell wall biogenesis. A variety of coupling methods have been investigated before finding satisfactory techniques useful for thiofuranoses. Reductive deprotection of the sulfur-containing species is problematic, though lithium naphthalenide has proved to be an effective technique.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.sourceIJCB Vol.47B(11) [November 2008]en_US
dc.subjectTuberculosisen_US
dc.subjectGlycosyl inhibitorsen_US
dc.subjectMycobacterial arabinogalactanen_US
dc.subjectThiofuranoses thioarabinofuranosyl disaccharidesen_US
dc.titleSynthesis of 4-deoxy-4-thioarabinofuranosyl disaccharides, analogs of Mycobacterial arabinogalactanen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.47B(11) [November 2008]

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