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Title: Quercetin and β-sitosterol prevent high fat diet induced dyslipidemia and hepatotoxicity in Swiss albino mice
Authors: Sikder, Kunal
Das, Nilanjan
Kesh, Swaraj Bandhu
Dey, Sanjit
Keywords: β-sitosterol;Dyslipidemia;Hepatotoxicity;Quercetin;Steatosis
Issue Date: Jan-2014
Publisher: NISCAIR-CSIR, India
Abstract: High fat diet group showed a significant rise in serum and hepatic total cholesterol, triglyceride and atherogenic index which are major biomarkers of dyslipidemia and cardiovascular risk. The liver function markers, lipid peroxidation and proinflammatory cytokine levels were elevated in high fat diet group whereas antioxidant levels significantly reduced. These findings manifest hepatic damage which was further confirmed by histological findings. Quercetin and β-sitosterol though structurally different yet both ameliorate the sickening changes in different mechanism. The current investigation is perhaps the first report of the mechanistic role of two polyphenols over dyslipidemia and subsequent hepatotoxicity.
Page(s): 60-66
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.52(01) [January 2014]

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