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Title: Synthesis, antituberculosis and antimicrobial study of some new aminoacridine linked pyrazoles
Authors: Kawle, P R
Deohate, P P
Berad, B N
Srivastava, K K
Sharma, P
Keywords: Pyrazole;Hydrazine;Acid hydrazides;Antitubercular screening;Antimicrobial
Issue Date: Dec-2013
Publisher: NISCAIR-CSIR, India
Abstract: Synthesis of heterocycles containing pyrazole linked to acridine chromophore has been studied and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis. Acridin-9-yl-(5-methyl-2-aryl)-2,4-dihydropyrazol-3-ylidene)-amine and [5-(acridin-9-yl-imino)-3-methyl-4,5-dihydro-pyrazol-1-yl]-pyridin-4-yl/aryl-methanone have been prepared by cyclocondensation reaction of N-acridin-9-yl-3-oxo-butyramide with hydrazine hydrate in ethanol at room temperature. The title compounds have been screened for their antimicrobial potency against some selected microorganisms to set-up structure activity relationship. All the compounds are found to have potent antimicrobial response. The structural elucidation of synthesised compounds has been performed by IR, 1H NMR and mass spectroscopic data besides elemental analysis. The products are obtained by a simple methodology and in good yields.
Page(s): 1531-1535
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.52B(12) December 2013]

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