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Title: In-silico, in-vitro antibacterial activity and toxicity profile of new quinoline derivatives
Authors: Sambavekar, P P
Aitawade, M M
Patil, D R
Kolekar, G B
Deshmukh, M B
Anbhule, P V
Keywords: Quinoline derivatives;PASS;Antibacterial activity;Staphylococcus aureus;Escherichia coli;Brine shrimp
Issue Date: Dec-2013
Publisher: NISCAIR-CSIR, India
Abstract: The new substituted quinoline derivatives have been synthesized and characterized by various spectroscopic techniques. A prediction of activity spectra for substances (PASS) of synthesized quinoline compounds showed their probabilities of being active for the antibacterial activities. Therefore, all the newly synthesized compounds have been evaluated for their in-vitro antibacterial activity against Staphylococcus aureus and Escherichia coli. It has been observed that 6-chloro-4-phenylquinoline-2,3-dicarboxylic acid 4a selectively active against Gram (-)ve E. coli and 8-chloro-10-phenyl-2,3-dihydropyridazino[4,5-b]quinoline-1,4-dione 5a showed selectivity against Gram (+)ve S. aureus. PASS prediction study indicates that the compound 5a as a potential candidate with a Pa 0.671, maximum from the series. According to the results obtained from brine shrimp (Artemia salina) lethality bioassay the compounds prove to be non toxic. The computer aided results are in good agreement with experimental results.
Page(s): 1521-1526
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.52B(12) December 2013]

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