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|Title:||Conventional as well as microwave assisted synthesis and microbial effect of some new acrylamides|
|Keywords:||α,β-Unsaturated acids;Boric acid;Acrylamides;Bacillus sp.;Pseudomonas sp.;Ensifer sp.|
|Abstract:||Knoevenagal condensation reaction has been used for the synthesis of α,β- unsaturated acids. The different aldehydes have been reacted with acetic acid in the presence of sodium borohydride to give the corresponding acrylic acids which have been reacted with furfural amine and 2-aminopyridine in the presence of catalytic amount of boric acid to synthesize corresponding acrylamides. All the synthesized acids and amide derivatives have been characterized by spectral data (IR and 1H NMR) and CHN analysis. All amide derivatives have also been prepared by microwave irradiation method by irradiating the mixture of corresponding acrylic acids and amines that gave higher yield and took less time. Amide derivatives have been screened for their microbial activity against bacteria viz. Bacillus sp. (BSY 101), Pseudomonas sp. (LK 791) and Ensifer sp. (IND 2), fungus Ascochyta blight and yeast (Sacchromyces cerevisiae). It have been found that the synthesized amide derivatives show poor inhibition against Bacillus sp., Pseudomonas sp. and Ensifer sp. Maximum 9-10 mm inhibition zones have been observed for those amide derivatives having 2-chloro, 2-methoxy and 4-methoxy group substitution on phenyl ring and pyridine moiety. The decrease in growth of bacteria by some amide derivatives is due to substitution on phenyl ring by nitro, chloro and methoxy groups. The pyridine moiety containing compounds have been found to be more effective against bacteria than furfural moiety. All amide derivatives are ineffective growth inhibitors for fungus and yeast.|
|Appears in Collections:||IJC-B Vol.52B(12) December 2013]|
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