Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/24772
Title: Iodine catalyzed three-component synthesis of β-amino-β-keto-esters and their antimicrobial activity
Authors: Kataki, Dolly
Bhattacharyya, Pranabananda
Deka, Manab
Jha, Dhruba Kumar
Keywords: Three-component Mannich reaction;MCR;Iodine;β-amino carbonyl compounds;Solvent-free;Antifungal;Antibacterial
Issue Date: Dec-2013
Publisher: NISCAIR-CSIR, India
Abstract: A series of β-amino-β-keto-esters have been prepared in moderate to good yields by a three-component Mannich reaction of aldehydes, benzyl carbamate and β-keto esters in the presence of iodine catalyst under solvent-free condition. All compounds have been tested for antibacterial and antifungal activities. Antagonistic activity of these compounds have been tested in vitro against three gram positive bacteria (Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermitidis), two gram negative bacteria (Escherichia coli, Klebsiella pneumoniae) and two pathogenic fungi (Candida albicans and Candida tropicalis) using agar-cup diffusion method. The bioassay result of these compounds in present investigation indicates promising antimicrobial activity against both the bacterial and fungal pathogens. The minimum inhibitory concentration (MIC) of the potent compounds range between 125 to 3000 µg/mL.
Page(s): 1505-1512
URI: http://hdl.handle.net/123456789/24772
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.52B(12) December 2013]

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