Please use this identifier to cite or link to this item:
Title: Synthesis and antimicrobial activity of pyrazolinone and pyrazole analogues containing quinoline moiety
Authors: Amir, Mohd
Javed, Sadique A
Hassan, Mohd Zaheen
Keywords: Quinoline;Pyrazolinone;Pyrazole;Antimicrobial activity
Issue Date: Dec-2013
Publisher: NISCAIR-CSIR, India
Abstract: A new class of quinoline derivatives containing pyrazoline-5-one and pyrazole moiety (3a-j and 4a-j) have been synthesized by condensation of various oxobutyrates/pentane-2,4-dione derivatives with 8-quinolinoxyacetic acid hydrazide. Elemental analysis, IR, 1H NMR and mass spectral data support the structures of the newly synthesized compounds. The synthesized compounds have been evaluated for their antimicrobial activity against S. aureus, E. coli, A. niger and C. albicans using serial plate dilution method. Compound 4-(2-(4-fluorophenyl)hydrazono)-3-methyl-1-(2-(quinolin-8-yloxy) acetyl)-1H-pyrazol-5(4H)-one 3f having log P 1.52 has emerged as the most potent antimicrobial agent of the series.
Page(s): 1493-1499
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.52B(12) December 2013]

Files in This Item:
File Description SizeFormat 
IJCB 52B(12) 1493-1499.pdf87.71 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.