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Title: Mechanistic study of oxidation of sulfacetamide by diperiodatocuprate(III) in aqueous alkaline medium
Authors: Naik, P N
Kulkarni, S D
Chimatadar, S A
Nandibewoor, S T
Issue Date: Nov-2008
Publisher: CSIR
IPC Code: Int. Cl. ⁸ : C07B33/00
Abstract: The oxidation of sulfacetamide, a sulfonamide drug, by alkaline diperiodatocuprate(III) has been studied at 298 K and at constant ionic strength. The reaction is first order in diperiodatocuprate(III) and has less than unit order in sulfacetamide concentration. The rate constants increase with increase in alkali concentration and decrease with increase in periodate concentration. A mechanism has been proposed wherein monoperiodatocuprate(III) is the active species. The reaction constants involved in the different steps of the mechanism and the activation parameters for the slow step have been computed.
Page(s): 1666-1670
ISSN: 0376-4710
Appears in Collections:IJC-A Vol.47A(11) [November 2008]

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