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Title: Characterization and nuclease activity of mixed ligand Ni(II) complexes
Authors: Babu, M S Surendra
Krishna, P G
Reddy, K Hussain
Philip, G H
Issue Date: Nov-2008
Publisher: CSIR
IPC Code: Int. Cl. ⁸ : C07F15/04
Abstract: Mixed ligand complexes having molecular formulae Ni(L)₂ (L')₂ [where LH = salicylaldoxime(SAO) or 2-hydroxy-acetophenone oxime (HAO); L' = pyridine or imidazole] have been synthesized and characterized by elemental analysis, molar conductivity, magnetic susceptibility, UV-vis and IR spectra. The magnetic moment and UV data suggest square planar geometry for parent complexes and octahedral geometry for mixed ligand complexes. Electrochemical studies have been carried out by cyclic voltammetry. The active signals are assignable to the Niˡˡ′ˡ redox couple. Binding of metal complexes with calf thymus DNA is revealed by absorption spectrophotometry. The cleavage activity of complexes has been carried out on a double stranded pBR 322 circular plasmid DNA by using gel electrophoresis in the presence and in the absence of oxidant (H₂O₂).
Page(s): 1661-1665
ISSN: 0376-4710
Appears in Collections:IJC-A Vol.47A(11) [November 2008]

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