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Title: Drug release and antimicrobial studies on chitosan-coated cotton yarns
Authors: Shanmugasundaram, O L
Dev, V R Giri
Neelakandan, R
Madhusoothanan, M
Rajkumar, G Suseela
Keywords: Chitosan;Coated yarn;Cotton;Drug release;Sodium periodate;Tetracycline hydrochloride
Issue Date: Dec-2006
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8 A61Ll5/00, D06B3/00
Abstract: Cotton yarns coated with chitosan have been prepared by the oxidation of cotton yarns with sodium periodate at 60°C in water and subsequent treatment with a solution of chitosan in aqueous acetic acid. Infrared spectra of the chitosan-coated cotton yarn show the formation of Schiffs base between the chitosan and the oxidized cellulose. The chitosan-coated yarns have been further immobilized with tetracycline drug and the effect of drug concentration and treatment time on drug release characteristics and antimicrobial activity studied. The study shows good drug release characteristics and antimicrobial activity against E.coli and S. aureus.
Page(s): 543-547
ISSN: 0975-1025 (Online); 0971-0426 (Print)
Appears in Collections:IJFTR Vol.31(4) [December 2006]

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