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|Title:||Synthetic and antibacterial studies of rhodanine derivatives with indol-2,3-diones|
|Authors:||Pardasani, R T|
|Abstract:||A facile synthesis of new isatylidene and quinoline derivatives is described by treatment of rhodanine with indol-2,3-diones via Knoevenagel condensation and Pfitzinger reaction respectively. The reaction of indol-2,3-dione derivatives with five membered heterocycles, viz rhodanine under normal and basic conditions is described. While refluxing with ethanol it afford 3,4-dihydro-3-[2-thioxo-4 –thiazolidinone]indol-2-one 3, under basic conditions l-methyl-2-thio-4-thiazolidino[5,4-b] quinoline-4-carboxylic acid 4 is obtained. The compounds 3 and 4 have been characterized by spectral studies and elemental analyses and screened for antibacterial activity.|
|Appears in Collections:||IJC-B Vol.40B(12) December 2001]|
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