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Title: Synthesis and antibacterial activity of some new [1,3,4] oxadiazino [6,5-b] indoles and acetophenonehydrazones containing 1,8- naphthyridine moiety
Authors: Mogilaiah, K
Babu, H Ramesh
Rao, R Babu
Issue Date: Dec-2001
Publisher: NISCAIR-CSIR, India
Abstract: Condensation of 1,8-naphthyridin-2-one-3-carboxylic acid hydrazide 1 with different isatins 2 gives the corresponding isatin-β-(1,8-naphthyridin-2-one-3-carbonylhydrazones) 3, which on treatment with cone. H2SO4 undergo cyclodehydration to afford the desired 2-(1,8-naphthyridin-2-one-3-yl)-[1,3,4]oxadiazino[6,5-b] indoles 4. On the other hand, the reaction of 1 with different acetophenones furnished the respective acetophenone 1,8- naphthyridin-2-one-3-carbonylhydrazones 5. The structural assignment of the products is based on elemental analyses and spectral data. The compounds 4 and 5 have been evaluated for their antibacterial activity against E. coli, P. aeruginosa, B. subtilis and B. mycoides.
Page(s): 1270-1274
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(12) December 2001]

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