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Title: Antinociceptive activity of a neurosteroid tetrahydrodeoxycorticosterone (5α-pregnan-3α-21-diol-20-one) and its possible mechanism(s) of action
Authors: Mediratta, P K
Gambhir, M
Sharma, K K
Ray, M
Issue Date: Dec-2001
Publisher: NISCAIR-CSIR, India
Abstract: The present study investigates the effects of a neurosteroid tetrahydrodeoxycorticosterone (5α-pregnan-3α-21-diol-20- one) in two experimental models of pain sensitivity in mice.  Tetrahydrodeoxycorticosterone (2.5, 5 mg/kg, ip) dose dependently decreased the licking response in formalin test and increased the tail flick latency (TFL) in tail flick test. Bicuculline (2 mg/kg, ip), a GABAA receptor antagonist blocked the antinociceptive effect of tetrahydrodeoxycorticosterone in TFL test but failed to modulate licking response in formalin test. Naloxone (1 mg/kg, ip), an opioid antagonist effectively attenuated the analgesic effect of tetrahydrodeoxycorticosterone in both the models. Tetrahydrodeoxycorticosterone pretreatment potentiated the antinociceptive response of morphine, an opioid compound and nimodipine, a calcium channel blocker in formalin as well as TFL test. Thus, tetrahydrodeoxycorticosterone exerts an analgesic effect, which may be mediated by modulating GABA-ergic and/or opioid-ergic mechanisms and voltage-gated calcium channels.
Page(s): 1299-1301
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.39(12) [December 2001]

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