Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBhattacharya, Salil K.-
dc.contributor.authorBhattacharya, Dipankar-
dc.contributor.authorMuruganandam, A.V.-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.description.abstractEffect of active tannoid principles of E. officinalis, comprising of emblicanin A (37%), emblicanin B (33%), punigluconin (12%) and pedunculagin (14%), was investigated on a rat model of tardive dyskinesia (TD) induced by once daily administration of haloperidol (1.5 mg/kg, ip) for 28 days. Involuntary oro facial movements (chewing movements, buccal tremors and tongue prolusion) were assessed as TO parameters. The tannoid principles of £.officina/is (EOT) wery administered concomitantly with haloperidol in the doses of 10, 20 and 50 mg/kg, po, for 28 days. Sodium valproate (200 mg/kg, po), a Gaba-mimetic agent, and vitamin E (400 mg/kg, po), an antioxidant, were used as the standard drugs and administered for the same period. EOT induced a dose-related inhibition of all the three TD parameters assessed, as did vitamin E. The effect of sodium valproate remained statistically insignificant. The results suggest that EOT exerts a prophylactive effect against neuroleptic-induced TD which is likely to be due to its earlier reported antioxidant effects in rat brain areas, including striatum.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.38(09) [September 2000]en_US
dc.titleEffect of Emblica officinalis tannoids on a rat model of tardive dyskinesiaen_US
Appears in Collections:IJEB Vol.38(09) [September 2000]

Files in This Item:
File Description SizeFormat 
IJEB 38(9) 945-947.pdf681.47 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.