Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/24086
Title: Effect of Emblica officinalis tannoids on a rat model of tardive dyskinesia
Authors: Bhattacharya, Salil K.
Bhattacharya, Dipankar
Muruganandam, A.V.
Issue Date: Sep-2000
Publisher: NISCAIR-CSIR, India
Abstract: Effect of active tannoid principles of E. officinalis, comprising of emblicanin A (37%), emblicanin B (33%), punigluconin (12%) and pedunculagin (14%), was investigated on a rat model of tardive dyskinesia (TD) induced by once daily administration of haloperidol (1.5 mg/kg, ip) for 28 days. Involuntary oro facial movements (chewing movements, buccal tremors and tongue prolusion) were assessed as TO parameters. The tannoid principles of £.officina/is (EOT) wery administered concomitantly with haloperidol in the doses of 10, 20 and 50 mg/kg, po, for 28 days. Sodium valproate (200 mg/kg, po), a Gaba-mimetic agent, and vitamin E (400 mg/kg, po), an antioxidant, were used as the standard drugs and administered for the same period. EOT induced a dose-related inhibition of all the three TD parameters assessed, as did vitamin E. The effect of sodium valproate remained statistically insignificant. The results suggest that EOT exerts a prophylactive effect against neuroleptic-induced TD which is likely to be due to its earlier reported antioxidant effects in rat brain areas, including striatum.
Page(s): 945-947
URI: http://hdl.handle.net/123456789/24086
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.38(09) [September 2000]

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