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Title: Hepatoprotective action of abhrak bhasma, an Ayurvedic drug in albino rats against hepatitis induced by CCl4
Authors: Buwa, Savita
Patil, Subhash
Kulkarni, P H
Kanase, Aruna
Issue Date: Oct-2001
Publisher: NISCAIR-CSIR, India
Abstract: Abhrak bhasma is a commonly used ayurvedic drug against many diseases including hepatitis. It is tested in albino rats using a model of hepatitis induced by a single dose of CCl4 (3 ml/kg body wt). Different doses of abhrak bhasma (10, 20, 30 and 40 mg/kg body wt) were tested to decide the dose related hepatoprotective efficacy. The centrolobular necrosis induced by single dose of CCl4 was reduced significantly by abhrak bhasma (10 mg) and liver histology was also protected by 20 mg dose. Liver acid lipase activity was lowered, while alkaline and lipoprotein lipase activities were elevated due to treatment of single dose of CCI4. Abhrak bhasma counteracted the action of CCI4 on liver lipolytic enzymes. CCl4 did not alter the kidney histologically. Activities of three lipases of rat kidney (acid, alkaline and lipoprotein lipases) were reduced by CCI4 treatment and were reversed by administration of abhrak bhasma. Acid lipase activity of rat adipose tissue was reduced by CCI4 treatment. On the contrary alkaline, lipoprotein and hormone sensitive lipases were enhanced after 24 hr of administration of CCI4 . Acid lipase activity was raised by administration of different doses of abhrak bhasma concurrent with CCI4. Abhrak bhasma treatment along with CCI4 enhanced alkaline lipase activity at 10 and 20 mg dose and later it was ┬áreduced at 30 and 40 mg doses and came to normal levels. Lipoprotein and hormone sensitive lipases were reduced by the counteraction of increasing doses of abhrak bhasma.
Page(s): 1022-1027
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.39(10) [October 2001]

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