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|Title:||Experimental evidence for a non-renin mediated pathway during TAME-esterase induced contractions in rat aorta in vitro|
|Authors:||Gurib, F B H|
Subratty, A H
|Abstract:||Possible pharmacological effects of N-α-tosyl L-arginine methyl ester [TAME] were studied on rat aorta strips in vitro. Results showed that [TAME]-esterase was an endothelium dependent component that involved a nitric oxide cyclic-GMP mediated pathway. Furthermore, during activation of Kinin-Kallikrein system, TAME-esterase induced contractions involve degradation of kinins by kininases.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.39(09) [September 2001]|
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