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Title: Experimental evidence for a non-renin mediated pathway during TAME-esterase induced contractions in rat aorta in vitro
Authors: Gurib, F B H
Subratty, A H
Issue Date: Sep-2001
Publisher: NISCAIR-CSIR, India
Abstract: Possible pharmacological effects of N-α-tosyl L-arginine methyl ester [TAME] were studied on rat aorta strips in vitro. Results showed that [TAME]-esterase was an endothelium dependent component that involved a nitric oxide cyclic-GMP mediated pathway. Furthermore, during activation of Kinin-Kallikrein system, TAME-esterase induced contractions involve degradation of kinins by kininases.
Page(s): 929-932
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.39(09) [September 2001]

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