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Title: Role of gastric antioxidant and anti-Helicobactor pylori activities in anti ulcerogenic activity of plantain banana (Musa sapientum var. paradisiaca)
Authors: Goel, R K
Sairam, K
Rao, Ch V
Raman, A
Issue Date: Jul-2001
Publisher: NISCAIR-CSIR, India
Abstract: Studies with plantain banana (Musa sapientum var. paradisiaca) have indicated its ulcer protective and healing activities through its predominant effect on various mucosal defensive factors [Sanyal, Arch Int Pharmacodyn. 149 (1964) 393; 155 ( 1965) 244]. Oxidative stress and Helicobactor pylori colonization are considered to be important factors in the pathogenesis of gastric ulcers. In the present study methanolic extract of plantain banana pulp (BE) was evaluated for its (i) antiulcer and antioxidant activities in 2 hr cold restraint stress and (ii) anti-H.pylori activity in vitro. The extract (BE, 50 mg/kg, twice daily for 5 days) showed significant antiulcer effect and antioxidant activity in gastric mucosal homogenates, where it reversed the increase in ulcer index, lipid peroxidation and super oxide dismutase values induced by stress.However it did not produce any change in catalase values, which was significantly decreased by stress. Further, in the in vitro study. BE (0.32 - 1000 µg/ml) did not show any anti-H.pylori activity. The results suggest absence of anti -H.pylori activity of methanolic extract of banana in vitro and its antioxidant activity may be involved in its ulcer protective activity.
Page(s): 719-722
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.39(07) [July 2001]

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