Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/23814
Title: Pre-electroconvulsive shock administration of calcium channel blockers reduces retrograde amnesia induced by ECS
Authors: Sushma, M
Sudha, S
Guido, S
Keywords: Electroconvulsive shock;Retrograde amnesia;Calcium channel blockers;Verapamil;Diltiazem;Nifedipine;Nimodipine;Flunarizine;Cinnarizine
Issue Date: Nov-2004
Publisher: NISCAIR-CSIR, India
Abstract: Effect of pre-electroconvulsive shock (ECS) administration of calcium channel blockers (CCBs) like verapamil, diltiazem, nifedipine, nimodipine, flunarizine and cinnarizine on retrograde amnesia induced by ECS was examined using passive avoidance paradigm in rats. The groups (Gr 1-7) of adult, male Wistar rats received true ECS with CCBs (5mg/kg; i.p) or vehicle (10 ml/kg; ip) and other groups (Gr 8-14) received sham ECS with CCBs (5mg/kg; i.p) or vehicle (10 ml/kg; i.p). The anti-amnestic activity of CCBs were evaluated using the passive avoidance paradigm in rats. Results showed that, the baseline latencies for all the groups did not differ significantly. Rats receiving true ECS produced significantly lower latencies. There was increase in the post ECS step through latencies of the rats administered CCBs before ECS. Therefore, pre-ECS administration of calcium channel blockers might reduce retrograde amnesia produced by ECS without altering seizure duration.
Page(s): 1141-1144
URI: http://hdl.handle.net/123456789/23814
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(11) [November 2004]

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