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Title: Effect of cadmium and zinc-metallothionein on methemoglobin and nitric oxide in dimethylnitrosamine treated rats
Authors: Rana, S V S
Kumar, Ajay
Keywords: Dimethylnitrosamine;Metallothionein;Methemoglobin;Nitric oxide
Issue Date: May-2001
Publisher: NISCAIR-CSIR, India
Abstract: Protective effects of metallothionein (MT) have been studied against dimethylnitosamine (DMN) toxicity in laboratory rats. MT was induced by feeding rats on repeated sublethal doses of cadmium and zinc. These rats were subsequently administered DMN. Methemoglobin and nitric oxides, the established markers of DMN toxicity, were estimated in the blood samples of MT protected rats. Pre induction of MT decreased methemoglobin and ameliorated the generation of nitric oxides. Anti oxidative effects of MT may have manifested these results, however, an effect on N-nitrosation is also speculated.
Page(s): 487-489
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.39(05) [May 2001]

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