|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.45 [2008] >
IJBB Vol.45(5) [October 2008] >
| Title: | Suppressive effect of Strychnos nux-vomica on induction of ovalbumin-specific IgE antibody response in mice |
| Authors: | Duddukuri, Govinda Rao
Brahmam, A Naga
Rao, D N |
| Keywords: | Strychnos nux-vomica
Immunomodulation
Immunosuppression
IgE antibody response
Passive cutaneous |
| Issue Date: | Oct-2008 |
| Publisher: | CSIR |
| Abstract: | Strychnos nux-vomica Linn. (SNV; Loganiaceae), a medicinal
plant has been used as folk medicine for alleviating inflammation,
joint pains and allergic symptoms. In the present study, we
examined its possible immunomodulatory effect on induction of
ovalbumin (OVA)-specific IgE antibody response in a murine
model, as evaluated by passive cutaneous anaphylaxis (PCA). The
OVA-specific IgE antibody response was significantly suppressed
in BALB/c mice (H-2d), following intraperitoneal administration
of aqueous stem extract of the plant along with OVA.
Furthermore, the different doses of SNV extract were found to
significantly suppress the induction of OVA-specific IgE antibody
response. The anti-OVA IgE antibody response was suppressed in
different haplotypes of mice viz., C57BL/6 (H-2b) and SWR/J
(H-2q). However, preliminary findings revealed no significant
change in the total IgG antibody response against OVA, as
evaluated by ELISA. These results confirm the suppressive
activity of S. nux-vomica on allergen-specific IgE antibody
response and suggest its possible application in allergic
conditions. |
| Page(s): | 341-344 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.45(5) [October 2008]
|
|
