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Title: Acute and subchronic toxicity of aflatoxin B1 to rohu, Labeo rohita (Hamilton)
Authors: Sahoo, P K
Mukherjee, S C
Nayak, S K
Dey, S
Issue Date: May-2001
Publisher: NISCAIR-CSIR, India
Abstract: Pathological alterations in various organs of rohu (L.rohita) fingerlings following acute (0,7.50, 11 .25 and 13.75 mg/kg body weight) and subchronic (0, 1.25 and 2.50 mg/kg body weight) single ip aflatoxin B 1 exposure for I 0 and 90 days, respectively, were investigated. Mortality (dose-dependent) was marked only during acute toxicosis. The changes observed in various organs were dose and time dependent. The acute dose groups revealed toxic changes viz., necrotic and vascular changes in liver and gill lamellae; meningitis, congestion in brain, degeneration and inflammatory reaction in heart along with degenerative to necrotic changes in kidney tubules and sloughing of the intestinal mucosa. During subchronic exposure to this toxin, preneoplastic lesions in liver along with changes in spleen, intestine, gi ll and pancreas were recorded. With low doses of aflatoxin, the fish did not reveal any mortality or external signs other than catchexia and increased pigmentation on scales. In composite culture practice of Indian major carps, this could be of economic significance.
Page(s): 453-458
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.39(05) [May 2001]

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