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|Title:||Antioxidant activity of brahma rasayana|
|Authors:||Rekha, P S|
|Abstract:||Free oxygen radical scavenging activity of brahma rasayana(BR) was studied by in vitro and in vivo models. Addition of aqueous extract of BR was found to scavenge the lipid peroxides already present in rat liver homogenate(IC50 700µg/ml) and inhibit the lipid peroxide generated by Fe2+ - ascorbate(IC50 2600µg/ml) and Fe3+- ADP - ascorbate system(IC50 1200µg/ml ). BR was found to scavenge the hydroxyl radical generated by Fenton reaction (IC50 7400µg/ ml) and superoxide generated by photoreduction of ribonavin (IC50 180µg/ml ). BR was also found to inhibit the nitric oxide radical generated in vitro from sodium nitroprusside (IC50 5.5µg/ml ). Oral administration of BR(50mg/dose/animal) was found to inhibit the PMA induced superoxide generation in mice peritoneal macrophages. Oral administration of BR; 10 and 50mg/dose/animal was also found to inhibit the nitrite production in peritoneal macrophages and percentage inhibition was 25.2% and 37.8% respectively. These results indicate significant antioxidant activity of BR in vitro and in vivo.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.39(05) [May 2001]|
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