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Title: Short-term effects of thyroid hormones on lipogenic enzymes and 14C-acetate incorporation into various lipid classes: In vivo and in vitro studies
Authors: Varghese, Sheelu
Shameena, B
Sudhakaran, P.R
Oommen, Oommen V.
Issue Date: May-2001
Publisher: NISCAIR-CSIR, India
Abstract: Short-term effect of 3,5,3' -triiodothyronine (T3) and 3,5-diiodothyronine (T2) on lipid metabolism in the liver of Anabas testudineus was examined. In vivo injections of both T3 and T2 at a concentration of 10 ng/g body weight increased malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) activity compared to 6-propylthiouracil (6-PTU) treated group. Treatment of 6-PTU results in the accumulat ion 14C-acetate into fat and thyroid hormones' treatment reduce it. In vitro experiment s show that malic enzyme activity is augmented only by high concentration of T3 (10-7 M) where as all concentrations of T2 increase its activity. In vitro studies with T3 showed a biphasic effect on cholesterol content. Conversely T2, in vitro, reduced cholesterol content with all concentrations. From these results it can be concluded that both T3 and T2 have short-term effect on lipid metabolism in Anabas.
Page(s): 431-435
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.39(05) [May 2001]

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