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Title: N-Phthaloyl gamma-aminobutyric acid affects biochemical circadian rhythms in Wistar rats
Authors: Subramanian, P
Sundaresan, S
Balamurugan, E.
Issue Date: Apr-2001
Publisher: NISCAIR-CSIR, India
Abstract: N-Phthaloyl gamma-aminobutyric acid (P-GABA) was administered to Wistar rats and 24 hr rhythms of glucose, cholesterol, total protein and lactic acid levels in blood were studied under semi-natural light dark conditions. P-GABA administration caused desynchronisation of the rhythms; while glucose and lactic acid rhythms were advanced, cholesterol and total protein rhythms were delayed. Since GABA is being involved in conveying dark information to the clock, exogenous administration of P-GABA may reduce the photic information received by the clock. The results could be explaincd by slightly less than I hr daily delays (or) advances respectively which would bring the peak times to the points 21 days after the start of administration.
Page(s): 360-364
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.39(04) [April 2001]

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