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Title: Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L.
Authors: Kumar, Vikas
Singh, P.N.
Bhattacharya, S.K.
Issue Date: Apr-2001
Publisher: NISCAIR-CSIR, India
Abstract: A standardised 50% aqueous ethanolic extract of the Indian variety of Hypericum perforatum (IHp) was examined for its putative anti-inflammatory and analgesic activity at the does of 100 and 200 mg/kg. po. The experimental paradigms used were carrageenan induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, whereas the tail flick, hot plate and acetic acid induced writhing methods were used to asses analgesic activity. Indomethacin (20 mg/kg, ip) was used as the standard anti-inflammatory drug. Pentazocine ( 10 mg/kg, ip) and aspirin (25 mg/kg, ip), both clinically used analgesics, were used as standard analgesics for comparison. IHp extract showed significant anti inflammatory and analgesic activity at both dose levels, in all the paradigms used. Additionally, IHp potentiated the antiinllammatory activity of indomethacin and analgesic activities of pentazocine and aspirin.
Page(s): 339-343
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.39(04) [April 2001]

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