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Title: Effect of Indigofera tinctoria Linn on liver antioxidant defense system during D-galactosamine I endotoxin- induced acute hepatitis in rodents
Authors: Sreepriya, M
Devaki, T
Balakrishna, K
Apparanantham, T
Issue Date: Feb-2001
Publisher: NISCAIR-CSIR, India
Abstract: Effects of pre-treatment with the alcoholic extract of I. tinctoria (500 mg/kg body wt/day, po for 21 days) on liver antioxidant defense system during acute hepatitis induced by D-galactosamine (D-GalN)/ endotoxin (LPS extracted by phenol water method from E. coli serotype 011l.B4; 300 mg and 30 µg/kg body wt/day, ip, 18 hr before the assay) were investigated on the activities of enzymic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase and glutathione- s-transferase, and levels of total reduced glutathione in the liver of normal and experimental groups of male albino rats. Since lipid peroxidation and associated membrane damage is a key feature of  D-galN/LPS-induced liver injury, the levels of lipid peroxides, was estimated and used as an index of oxidative stress. D-GalN/endotoxin-induced hepatic damage was manifested by a significant decrease in the activities of antioxidant  enzymes, decreased glutathione levels and increased levels of  lipid peroxides.I. tinctoria pre-treated rats showed considerable protection against D-galN/endotoxin, induced oxidative stress as evidenced by a significant increase in the activities of all the antioxidant enzymes studied and significant decrease in the levels of lipid peroxides. Results indicate that pretreatment with I. tinctoria extract in rats is very effective in reducing D-GalN/endotoxin-induced oxidative stress suggesting an antioxidant effect.
Page(s): 181-184
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.39(02) [February 2001]

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